At d77, D 2 25OHD levels were higher than those at baseline, but similar to placebo both were lower than D 3 ( P<0.04). The AUC was 28.6% higher for D 3 compared with D 2, and both were higher with respect to placebo. As after the loading dose both D 2 and D 3 groups had reached similar 25OHD levels, we tested equivalence of the area under the concentration × time curve (AUC) between d7 and d77. Results:īaseline 25OHD values in the D 2 group were lower than those in the D 3 and placebo groups ( P<0.01). Serum samples were obtained at baseline and at days 3, 7, 14, 21, 35, 49, 63 and 77. Treatment started with a loading dose (100 000 IU) followed by 4800 IU/day (d) between d7 and d20 and follow-up until d77. Healthy volunteers ( n=33, aged 33.4☖ years) were divided into three groups ( n=11, each): D 2, D 3 and placebo. To compare D 2 with D 3 we performed a single-blind, placebo-controlled randomized trial spanning 11 weeks.

The superiority of cholecalciferol (D 3) over ergocalciferol (D 2) in sustaining serum 25-hydroxy vitamin D (25OHD) levels is controversial.

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